A drug combination composed of clindamycin and tretinoin, Ziana is a topical treatment for acne. The composition is made up of 1.2% clindamycin phosphate, 0.025% tretinoin, an antibiotic, and a retinoid. Owing to its gel form, it is typically sold in 2g, 30g, and 60g tubes. This prescription medication should not be exposed to high temperatures and should be stored away from direct sunlight.
Ziana banks on the combined tretinoin and clindamycin content in order to combat acne by preventing the growth of bacteria which commonly form in the sebaceous gland, in which the increased production of sebum due to hormone imbalance could lead to a breakout of various skin ailments, the most common of which are pimples.
Ziana Cost Information
Price would vary depending on location and tube size. A typical large tube would costa round USD35, based on prices displayed on online pharmacies.
Dosage | Quantity | Price Without Insurance |
CVS Pharmacy |
| 30g of 1.2%/0.025% gel | 1 tube of gel | $314.78 |
| 60g of 1.2%/0.025% gel | 1 tube of gel | $673.00 |
Kmart |
| 30g of 1.2%/0.025% gel | 1 tube of gel | $320.75 |
| 60g of 1.2%/0.025% gel | 1 tube of gel | $675.00 |
Kroger |
| 30g of 1.2%/0.025% gel | 1 tube of gel | $316.03 |
| 60g of 1.2%/0.025% gel | 1 tube of gel | $706.00 |
Publix |
| 30g of 1.2%/0.025% gel | 1 tube of gel | $318.41 |
| 60g of 1.2%/0.025% gel | 1 tube of gel | $606.86 |
Rite Aid |
| 30g of 1.2%/0.025% gel | 1 tube of gel | $384.00 |
| 60g of 1.2%/0.025% gel | 1 tube of gel | $710.00 |
Target |
| 30g of 1.2%/0.025% gel | 1 tube of gel | $317.23 |
| 60g of 1.2%/0.025% gel | 1 tube of gel | $771.00 |
Walgreens |
| 30g of 1.2%/0.025% gel | 1 tube of gel | $363.00 |
| 60g of 1.2%/0.025% gel | 1 tube of gel | $731.00 |
Walmart |
| 30g of 1.2%/0.025% gel | 1 tube of gel | $311.70 |
| 60g of 1.2%/0.025% gel | 1 tube of gel | $595.11 |
Short-Term Side Effects
Owing to its nature as a topical medication, Ziana usually bring about skin-related side effects which are not limited to: redness, dryness, swelling, peeling, and itching. Exposure to direct sunlight during application could also lead to unwanted skin irritation. Swelling in certain parts of the face, as well as difficulty in breathing, has also been reported. Since every individual would have a different reaction to a certain type of medication, let alone a topical one, it would be best to consult a dermatologist first in order to determine what could trigger an allergic reaction. This is recommended even more so for Ziana because it is a treatment that usually involves the face, where side effects would be more obvious.
Long-Term Side Effects
There have been reports of rare cases involving diarrhea and colitis. If such symptoms start to manifest, stop medication and seek medical attention at once. Other than this, there are no known long-term side effects in using this medication.
How It Works
As a common treatment for acne, Ziana relies on its Clindamycin content, the main purpose of which is to prevent the growth of bacteria that usually form in sebaceous glands. Increased production of sebum, usually caused by hormone imbalance, is the main culprit in the clogging of pores, which consequently lead to various blemishes such as pimples and blackheads.
It is said that this medication could contribute to certain intestinal problems such as enteritis, colitis, and even Crohn’s disease. As such, it would be better to consult your doctor first before proceeding with the treatment. The same thing goes for pregnant and breastfeeding women.
Drug Interactions
The use of Ziana with other topical medication is not recommended, the most common one being erythromycin and benzoyl peroxide. Aside from this, other skin products such as soaps and cleansers are also not recommended to be used in tandem with Ziana, as they might contain substances that could prove to be harmful when mixed with either Clindamycin or tretinoin.
Generic Alternatives
Ziana is known by the generic name clindamycin/tretinoin, a combination drug which is also marketed under the brand name Veltin.
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